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Circulation Research. 1962;10:359-363

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(Circulation Research. 1962;10:359.)
© 1962 American Heart Association, Inc.

Effects of Bradykinin on the Systemic and Coronary Vascular Bed of the Intact Dog

G. M. MAXWELL M.D., M.R.C.P.1, R. B. ELLIOTT M.B., B.S.1, G. M. KNEEBONE M.B., M.R.A.C.P.1

1 Department of Child Health, University of Adelaide, Adelaide Children's Hospital, Inc., North Adelaide, South Australia

Bradykinin, in the circumstances of this study, increased heart rate, cardiac output, and coronary blood flow. Systemic, pulmonary, and coronary vascular resistances decreased; these changes were not entirely due to the decrease in systemic and pulmonary arterial pressures. The changes in myocardial oxygen and carbon dioxide metabolism were mostly related to the increase in coronary blood flow. Bradykinin was found to be associated with a decrease in cardiac efficiency.

Submitted on September 26, 1961




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