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Circulation Research. 1962;10:347-353

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(Circulation Research. 1962;10:347.)
© 1962 American Heart Association, Inc.

Mechanism of the Myocardial Effects of Bretylium

J. P. GILMORE M.S.1 J. H. SIEGEL M.D.1

1 Laboratory of Cardiovasuclar Physiology, National Heart Institute Bethesda, Maryland

The increased myocardial contractility resulting from the injection of bretylium has been shown to be accompanied by a myocardial release of catecholamines. Cardiac sympathetic nerve stimulation following bretylium is associated with neither an increased contractility nor a release of myocardial catecholamines. The failure to release catecholamines under these conditions does not result from depletion, but rather from a block of the nerve release mechanism.

Submitted on September 25, 1961




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