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Circulation Research. 1962;10:313-320

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(Circulation Research. 1962;10:313.)
© 1962 American Heart Association, Inc.

Evidence for a Prolonged Biological Half-Life of Na22 in Patients with Hypertension

LEWIS K. DAHL M.D.1, MALCOLM G. SMILAY M.D.1, LAWRENCE SILVER M.D.1, SANFORD SPRARAGEN M.D.1

1 Medical Research Center, Brookhaven National Laboratory Upton, New York

The biological half-life of Na22 was found to be significantly longer (p <0.01) in seven hypertensive adults than in eight normotensive adults on equivalent NaCl intakes. Calculations based on approximations of leanbody mass suggest that the hypertensive subjects may have a larger sodium pool to explain this disparity.

Submitted on September 11, 1961




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